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Article

Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and Atherosclerosis

19 Aug 2003

Abstract excerpt

The scavenger receptor class B type I (SR-BI) was the first molecularly well-defined cell-surface HDL receptor to be described. SR-BI mediates selective HDL cholesterol uptake by formation of a productive lipoprotein/receptor complex, which requires specific structural domains and conformation states of apolipoprotein A-I present in HDL particles. SR-BI is abundantly expressed in several tissues, including the...

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PMID: 12920050
DOI: 10.1161/01.atv.0000091363.28501.84

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Influence of the HDL Receptor SR-BI on Lipoprotein Metabolism and AtherosclerosisPMID 12920050Read ↗

Functional genomics of the human high-density lipoprotein receptor scavenger receptor BI: an old dog with new tricks.Semantic proximity Read ↗

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A targeted mutation in the murine gene encoding the high density lipoprotein (HDL) receptor scavenger receptor class B type I reveals its key role in HDL metabolism.Semantic proximity Read ↗

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Knockdown expression and hepatic deficiency reveal an atheroprotective role for SR-BI in liver and peripheral tissues.Semantic proximity Read ↗

Carboxy-terminal deletion of the HDL receptor reduces receptor levels in liver and steroidogenic tissues, induces hypercholesterolemia, and causes fatal heart disease.Semantic proximity Read ↗

Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease.Semantic proximity Read ↗

Increased apolipoprotein M induced by lack of scavenger receptor BI is not activated via HDL-mediated cholesterol uptake in hepatocytes.Semantic proximity Read ↗

Scavenger Receptor class B type I (SR-BI): A versatile receptor with multiple functions and actionsSemantic proximity Read ↗

Role of apoA-I, ABCA1, LCAT, and SR-BI in the biogenesis of HDL.Semantic proximity Read ↗

Structure and Localization of the Human Gene Encoding SR-BI/CLA-1Semantic proximity Read ↗

Genetic studies in mice and humans reveal new physiological roles for the high-density lipoprotein receptor scavenger receptor class B type I.Semantic proximity Read ↗

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