Article
[The deletion of La protein binding site in HBV RNA leads to instability of S gene mRNA].
Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Jul 2006
Lin Yuan-yuan, Lin Ju-sheng, Xie Na, Zhou Xiu-min, Song Yu-hu
Abstract excerpt
OBJECTIVE: To investigate the effect of deletion of the La protein binding site of HBV RNA, caused by its mutation, on the HBV S-mRNA stability of S gene, to study the role of the site in hepatitis B virus life cycle, and to try to find a new anti-HBV target in the future. METHODS: A HBV vector with mutation related to the La protein binding site was constructed using molecular cloning and PCR based site directed...
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