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Article

[Construction of whole-genome lamivudine-resistant hepatitis B virus mutant and its replication and expression in HepG2 cells].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 1 Jul 2007

Sun Jian, Wang Cheng, Wen Shu-juan, Wang Zhan-hui, Hou Jin-lin

Abstract excerpt

OBJECTIVE: To observe the changes of replication and antigen expressions of lamivudine-resistant hepatitis B virus (HBV) with polymerase gene mutation. METHODS: With site-directed mutagenesis, we constructed 3 HBV plasmids with polymerase gene mutation based on the template P3.8II. All the plasmids were transfected into HepG2 cells, in which the replication and expression of the virus were analyzed. RESULTS: The...

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Source

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PMID: 17666334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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