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Article

[Construction of whole-genome lamivudine-resistant hepatitis B virus mutant and its replication and expression in HepG2 cells].

Nan fang yi ke da xue xue bao = Journal of Southern Medical University - 1 Jul 2007

Sun Jian, Wang Cheng, Wen Shu-juan, Wang Zhan-hui, Hou Jin-lin

Abstract excerpt

OBJECTIVE: To observe the changes of replication and antigen expressions of lamivudine-resistant hepatitis B virus (HBV) with polymerase gene mutation. METHODS: With site-directed mutagenesis, we constructed 3 HBV plasmids with polymerase gene mutation based on the template P3.8II. All the plasmi...

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PMID: 17666334

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17666334-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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