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Article

Successful establishment and evaluation of a new animal model for studying the hepatitis B virus YVDD mutant.

Archives of virology - 1 Apr 2013

Ma Yan-Xiu, Song Zhi-Wei, Teng Xu, Fu Li-Juan, Hao Mei-Li, Chen Si-Jia, Xu Wei-Zhen, Gu Hong-Xi

Abstract excerpt

The treatment of infection with lamivudine-resistant mutants of hepatitis B virus (HBV) with mutations in the YMDD motif has become a crucial issue in the clinic. In this work, the plasmids pcDNA3.1 (+)-HBV/C-YVDD and pcDNA3.1 (+)-HBV/C-YMDD were constructed and injected into BALB/c mice using a hydrodynamics-based procedure to investigate viral replication and expression of HBV lamivudine-resistant YVDD mutants...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Hepatitis B e Antigens

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Share to Hepatitis, Viral, Animal

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Identifiers

PMID: 23183771
DOI: 10.1007/s00705-012-1550-1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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