Article
Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett Esophagus?
The American journal of surgical pathology - 1 Mar 2012
Khor Tze Sheng, Alfaro Eduardo E, Ooi Esther M M, Li Yuan, Srivastava Amitabh, Fujita Hiroshi, Park Youn, Kumarasinghe Marian Priyanthi, Lauwers Gregory Yves
Abstract excerpt
Dysplasia in Barrett esophagus has been recognized to be morphologically heterogenous, featuring adenomatous, foveolar, and hybrid phenotypes. Recent studies have suggested a tumor suppressor role for CDX-2 in the metaplasia-dysplasia-carcinoma sequence. The phenotypic stability and role of CDX-2 in the neoplastic progression of different types of dysplasias have not been evaluated. Thirty-eight endoscopic...
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