Article
Genetic susceptibility to ulcerative colitis in the Chinese Han ethnic population: association with TNF polymorphisms.
Chinese medical journal - 20 Jul 2006
Cao Qian, Zhu Qin, Wu Min-liang, Hu Wei-ling, Gao Min, Si Jian-min
Abstract excerpt
BACKGROUND: Tumor necrosis factor alpha (TNFalpha) is an important proinflammatory cytokine that has been implicated in the pathogenesis of inflammatory bowel disease (IBD). Recent studies have evaluated the role of TNF promoter polymorphisms in IBD, whereas the data are inconsistent. Trans-racial mapping in an ethnically distinct but homogenous population may help clarify these associations. We investigate the...
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