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Article

Tumor necrosis factor-alpha polymorphisms in ulcerative colitis-associated colorectal cancer.

The American journal of gastroenterology - 1 Feb 2008

Garrity-Park Megan M, Loftus Edward V, Bryant Sandra C, Sandborn William J, Smyrk Thomas C

Abstract excerpt

OBJECTIVES: Ulcerative colitis (UC) is characterized by chronic recurrent mucosal inflammation. Genetic studies in UC have indicated linkage to chromosome 6 in the region of the tumor necrosis factor-alpha (TNF-alpha) gene, a potent proinflammatory cytokine. TNF-alpha production is influenced by multiple factors including the type of immune cell and its level of activation. However, several single nucleotide...

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Source

Identifiers

PMID: 18289203
DOI: 10.1111/j.1572-0241.2007.01572.x

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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