Article
Association of TNF-alpha-857C with inflammatory bowel disease in the Australian population.
Scandinavian journal of gastroenterology - 1 May 2003
O'Callaghan N J, Adams K E, van Heel D A, Cavanaugh J A
Abstract excerpt
BACKGROUND: It is now well established that susceptibility to inflammatory bowel disease is in part genetic, with one localization on chromosome 6 (IBD3) having been replicated in a number of populations. A candidate in that region, TNF-alpha, contains polymorphisms in the promoter region that appear to be associated with disease. METHODS: More than 600 individuals from 170 multiplex IBD families were genotyped...
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