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Article

Functional characterization of a full length pregnane X receptor, expression in vivo, and identification of PXR alleles, in zebrafish (Danio rerio).

Aquatic toxicology (Amsterdam, Netherlands) - 15 Oct 2013

Bainy Afonso C D, Kubota Akira, Goldstone Jared V, Lille-Langøy Roger, Karchner Sibel I, Celander Malin C, Hahn Mark E, Goksøyr Anders, Stegeman John J

Abstract excerpt

The pregnane X receptor (PXR) (nuclear receptor NR1I2) is a ligand activated transcription factor, mediating responses to diverse xenobiotic and endogenous chemicals. The properties of PXR in fish are not fully understood. Here we report on cloning and characterization of full-length PXR of zebrafish, Danio rerio, and pxr expression in vivo. Initial efforts gave a cDNA encoding a 430 amino acid protein identified...

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Identifiers

PMID: 24121122
DOI: 10.1016/j.aquatox.2013.09.014
PMCID: PMC3873750

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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