Article
The effect of immunoglobulin VH gene mutation status and other prognostic factors on the incidence of major infections in patients with chronic lymphocytic leukemia.
Cancer - 1 Sept 2006
Francis Sebastian, Karanth Mamatha, Pratt Guy, Starczynski Jane, Hooper Laura, Fegan Chris, Pepper Chris, Valcarcel David, Milligan Donald W, Delgado Julio
Abstract excerpt
BACKGROUND: Infections are a major factor in the clinical course of chronic lymphocytic leukemia (CLL) and account for 30% to 50% of all deaths. The pathogenesis of infections in CLL is related to hypo-gamma-globulinemia, T-cell immune dysfunction, and the immunosuppressive effect of treatment. METHODS: The authors retrospectively assessed the correlations between new prognostic markers and types of infections...
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