Redefining the prognostic likelihood of chronic lymphocytic leukaemia patients with borderline percentage of immunoglobulin variable heavy chain region mutations.

doi:10.1111/bjh.16434

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Article

Redefining the prognostic likelihood of chronic lymphocytic leukaemia patients with borderline percentage of immunoglobulin variable heavy chain region mutations.

British journal of haematology - 1 Jun 2020

Raponi Sara, Ilari Caterina, Della Starza Irene, Cappelli Luca V, Cafforio Luciana, Piciocchi Alfonso, Arena Valentina, Mariglia Paola, Mauro Francesca R, Gentile Massimo, Cutrona Giovanna, Moia Riccardo, Favini Chiara, Morabito Fortunato, Rossi Davide, Gaidano Gianluca, Guarini Anna, Del Giudice Ilaria, Foà Robin

Abstract excerpt

In chronic lymphocytic leukaemia (CLL), caution is warranted regarding the clinical implications of immunoglobulin variable heavy chain region (IGHV) rearrangements with a 'borderline' (BL) percentage of mutations (i.e. 97-97·9% IGHV identity). We analysed the IGHV mutational status in 759 untreated CLL patients (cohort 1). BL-CLL (n = 36, 5%) showed a time to first treatment (TFT) similar to that of M-CLL...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Gene Rearrangement, B-Lymphocyte, Heavy Chain

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Somatic Hypermutation, Immunoglobulin

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PMID: 32064595
DOI: 10.1111/bjh.16434

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