Article
Polycomb and trithorax group proteins mediate the function of a chromatin insulator.
Cell - 20 Feb 1998
Gerasimova T I, Corces V G
Abstract excerpt
Chromatin boundaries or insulator elements affect the interaction between enhancers and promoters. The gypsy insulator contains two proteins, Su(Hw) and Mod(mdg4). Both proteins colocalize on several hundred sites on polytene chromosomes and are distributed in a punctated pattern in the nuclear matrix. Mutations in mod(mdg4) have properties characteristic of a trxG gene. In addition, mutations in trxG genes...
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