Article
The Arabidopsis chromatin-modifying nuclear siRNA pathway involves a nucleolar RNA processing center.
Cell - 14 Jul 2006
Pontes Olga, Li Carey Fei, Costa Nunes Pedro, Haag Jeremy, Ream Thomas, Vitins Alexa, Jacobsen Steven E, Pikaard Craig S
Abstract excerpt
In Arabidopsis thaliana, small interfering RNAs (siRNAs) direct cytosine methylation at endogenous DNA repeats in a pathway involving two forms of nuclear RNA polymerase IV (Pol IVa and Pol IVb), RNA-DEPENDENT RNA POLYMERASE 2 (RDR2), DICER-LIKE 3 (DCL3), ARGONAUTE4 (AGO4), the chromatin remodeler DRD1, and the de novo cytosine methyltransferase DRM2. We show that RDR2, DCL3, AGO4, and NRPD1b (the largest subunit...
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