Article
Valvular dystrophy associated filamin A mutations reveal a new role of its first repeats in small-GTPase regulation.
Biochimica et biophysica acta - 1 Feb 2014
Duval D, Lardeux A, Le Tourneau T, Norris R A, Markwald R R, Sauzeau V, Probst V, Le Marec H, Levine R, Schott J J, Merot J
Abstract excerpt
Filamin A (FlnA) is a ubiquitous actin binding protein which anchors various transmembrane proteins to the cell cytoskeleton and provides a scaffold to many cytoplasmic signaling proteins involved in actin cytoskeleton remodeling in response to mechanical stress and cytokines stimulation. Although the vast majority of FlnA binding partners interact with the carboxy-terminal immunoglobulin like (Igl) repeats of...
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