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Article

Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I.

PloS one - 10 Nov 2010

Mondal Subhanjan, Burgute Bhagyashri, Rieger Daniela, Müller Rolf, Rivero Francisco, Faix Jan, Schleicher Michael, Noegel Angelika A

Abstract excerpt

Filamin and Cortexillin are F-actin crosslinking proteins in Dictyostelium discoideum allowing actin filaments to form three-dimensional networks. GAPA, an IQGAP related protein, is required for cytokinesis and localizes to the cleavage furrow during cytokinesis. Here we describe a novel interact...

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Identifiers

PMID: 21085675
DOI: 10.1371/journal.pone.0015440
PMCID: PMC2978108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21085675-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Regulation of the actin cytoskeleton by an interaction of IQGAP related protein GAPA with filamin and cortexillin I.PMID 21085675Read ↗

Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins.Semantic proximity Read ↗

The IQGAP-related protein DGAP1 interacts with Rac and is involved in the modulation of the F-actin cytoskeleton and control of cell motility.Semantic proximity Read ↗

Biochemical and biological properties of cortexillin III, a component of Dictyostelium DGAP1-cortexillin complexes.Semantic proximity Read ↗

FilGAP, a Rho- and ROCK-regulated GAP for Rac binds filamin A to control actin remodelling.Semantic proximity Read ↗

Dictyostelium ACAP-A is an ArfGAP involved in cytokinesis, cell migration and actin cytoskeleton dynamics.Semantic proximity Read ↗

Rac1 is deactivated at integrin activation sites via an IQGAP1/filamin-A/RacGAP1 pathwaySemantic proximity Read ↗

Nap1 regulates Dictyostelium cell motility and adhesion through SCAR-dependent and -independent pathways.Semantic proximity Read ↗

GxcDD, a putative RacGEF, is involved in Dictyostelium development.Semantic proximity Read ↗

Filamin actin-binding and titin-binding fulfill distinct functions in Z-disc cohesion.Semantic proximity Read ↗

Rac1 GTPases control filopodia formation, cell motility, endocytosis, cytokinesis and development in Dictyostelium.Semantic proximity Read ↗

Dia1 and IQGAP1 interact in cell migration and phagocytic cup formation.Semantic proximity Read ↗

Filamin protects myofibrils from contractile damage through changes in its mechanosensory region.Semantic proximity Read ↗

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