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Article

Adenovirus-mediated gene transfer of FKHRL1 triple mutant efficiently induces apoptosis in melanoma cells.

Cancer biology & therapy - 1 Jul 2006

Gomez-Gutierrez Jorge G, Souza Vinicius, Hao Hong Ying, Montes de Oca-Luna Roberto, Dong Yan Bin, Zhou H Sam, McMasters Kelly M

Abstract excerpt

The PTEN/Akt signal pathway plays an important role in tumorigenesis. Mutations or deletions of PTEN have been observed in up to 60% of melanoma cell lines, resulting in PI3K/Akt activation. The Forkhead family of transcription factors induce apoptosis in their unphosphorylated forms and were recently reported to be a substrate of Akt kinase. In the present study, an adenovirus expressing a triple mutant (TM) of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p27

Share to Forkhead Box Protein O3

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Share to Gene Transfer Techniques

Share to Proto-Oncogene Proteins c-bcl-2

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Source

Identifiers

PMID: 16861905
DOI: 10.4161/cbt.5.7.2911

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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