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Article

Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines.

The Journal of thoracic and cardiovascular surgery - 1 Jan 2001

Pataer A, Smythe W R, Yu R, Fang B, McDonnell T, Roth J A, Swisher S G

Abstract excerpt

OBJECTIVE: Conventional treatment for mesothelioma is largely ineffective. We therefore evaluated the novel approach of adenoviral gene transfer of the proapoptotic Bcl-2 family member Bak in mesothelioma cancer cell lines, which are sensitive and resistant to adenoviral p53. METHODS: Binary adenoviral Bak (Ad/GT-Bak and Ad/GV16) and LacZ (Ad/GT-LacZ and Ad/GV16) vectors were used for transduction of the...

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Share to Adenoviridae
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11135160
DOI: 10.1067/mtc.2001.111419

Genes

REN

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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