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Article

Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Aug 2007

Wang Yu Fang, Jiang Chen Chen, Kiejda Kelly Anne, Gillespie Susan, Zhang Xu Dong, Hersey Peter

Abstract excerpt

PURPOSE: Given that inhibitors of mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase (MEK) are being introduced into treatment for melanoma, the present study was carried out to better understand the mechanism by which they may induce apoptosis of melanoma cells. EXPERIMENTAL DESIGN: A panel of human melanoma cell lines and fresh melanoma isolates was assessed for their sensitivity...

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Identifiers

PMID: 17652623
DOI: 10.1158/1078-0432.CCR-07-0665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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