Article
Apoptosis of human melanoma cells induced by inhibition of B-RAFV600E involves preferential splicing of bimS.
Cell death & disease - 2 Sept 2010
Jiang C C, Lai F, Tay K H, Croft A, Rizos H, Becker T M, Yang F, Liu H, Thorne R F, Hersey P, Zhang X D
Abstract excerpt
Bim is known to be critical in killing of melanoma cells by inhibition of the RAF/MEK/ERK pathway. However, the potential role of the most potent apoptosis-inducing isoform of Bim, Bim(S), remains largely unappreciated. Here, we show that inhibition of the mutant B-RAF(V600E) triggers preferential splicing to produce Bim(S), which is particularly important in induction of apoptosis in B-RAF(V600E) melanoma cells....
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