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Article

Repression of BIRC5/survivin by FOXO3/FKHRL1 sensitizes human neuroblastoma cells to DNA damage-induced apoptosis.

Molecular biology of the cell - 1 Apr 2009

Obexer Petra, Hagenbuchner Judith, Unterkircher Thomas, Sachsenmaier Nora, Seifarth Christoph, Böck Günther, Porto Verena, Geiger Kathrin, Ausserlechner Michael

Abstract excerpt

The phosphatidylinositol 3-kinase (PI3K)-protein kinase B (PKB) pathway regulates survival and chemotherapy resistance of neuronal cells, and its deregulation in neuroblastoma (NB) tumors predicts an adverse clinical outcome. Here, we show that inhibition of PI3K-PKB signaling in human NB cells induces nuclear translocation of FOXO3/FKHRL1, represses the prosurvival protein BIRC5/Survivin, and sensitizes to...

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Source

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Identifiers

PMID: 19211844
DOI: 10.1091/mbc.e08-07-0699
PMCID: PMC2663932

Genes

FOXO3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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