Article
LT(R192G), a non-toxic mutant of the heat-labile enterotoxin of Escherichia coli, elicits enhanced humoral and cellular immune responses associated with protection against lethal oral challenge with Salmonella spp.
Vaccine - 1 Apr 1998
Chong C, Friberg M, Clements J D
Abstract excerpt
In the current study we examined the ability of a novel mucosal adjuvant, LT(R192G), to enhance the humoral and cellular immune responses against killed Salmonella spp. and to affect protection against lethal oral challenge with wild-type organisms. Mice orally immunized with killed S. dublin in...
Topics
- Administration, Oral
- Animals
- Antibodies, Bacterial
- Antibody Formation
- Antibody Specificity
- Bacterial Toxins
- Cytokines
- Enterotoxins
- Escherichia coli Proteins
- Feces
- Female
- Immunity, Cellular
- Immunity, Mucosal
- Interferon-gamma
- Leukocytes, Mononuclear