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Article

Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation.

Blood - 1 May 2007

Morgado Ester, Albouhair Stéphanie, Lavau Catherine

Abstract excerpt

HOX genes, MEIS1, and FLT3 are frequently up-regulated in human myeloid leukemias. Meis1 cooperates with Hox genes to induce leukemias in mice, hypothetically the consequence of Meis1-induced Flt3 overexpression. To test this, we compared the properties of Flt3(-/-) and Flt3(+/+) progenitors transduced with Hoxa9 or Hoxa9/Meis1. In a myeloid clonogenic assay, Meis1 greatly enhanced the proliferation of...

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Share to Cell Line, Transformed
Share to Cell Transformation, Neoplastic
Share to fms-Like Tyrosine Kinase 3

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Leukemic

Share to Leukemia, Myeloid, Acute

Share to Myeloid Ecotropic Viral Integration Site 1 Protein

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Share to Proto-Oncogene Proteins c-myb

Source

Identifiers

PMID: 17202314
DOI: 10.1182/blood-2006-01-039586

Genes

FLT3
MEIS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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