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Identification of cooperative genes for NUP98-HOXA9 in myeloid leukemogenesis using a mouse model

29 Sept 2004

Abstract excerpt

The chromosomal translocation t(7; 11)(p15;p15), observed in human myeloid leukemia, results in a NUP98 and HOXA9 gene fusion. We generated a transgenic mouse line that specifically expressed the chimeric NUP98-HOXA9 gene in the myeloid lineage. While only 20% of the transgenic mice progressed to leukemia after a latency period, myeloid progenitor cells from nonleukemic transgenic mice still exhibited increased...

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PMID: 15454493
DOI: 10.1182/blood-2004-04-1508

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