Article
Generation and characterization of Lhx3GFP reporter knockin and Lhx3loxP conditional knockout mice.
Genesis (New York, N.Y. : 2000) - 1 Apr 2018
Xu Mei, Xie Xiaoling, Dong Xuhui, Liang Guoqing, Gan Lin
Abstract excerpt
LHX3, a LIM-homeodomain transcription factor, is broadly expressed in the developing pituitary, spinal cord, medulla, retina and inner ear, and plays essential roles during embryonic development. Mice with homozygous Lhx3 null mutation exhibit failure in the formation of pituitary gland and die perinatally. To facilitate the functional study of Lhx3 in mice, we engineered and characterized two novel Lhx3 mouse...
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