Article
BRAF and TERT promoter mutations in the aggressiveness of papillary thyroid carcinoma: a study of 653 patients.
Oncotarget - 5 Apr 2016
Jin Langping, Chen Endong, Dong Siyang, Cai Yefeng, Zhang Xiangjian, Zhou Yili, Zeng Ruichao, Yang Fan, Pan Chuanmeng, Liu Yehuan, Wu Weili, Xing Mingzhao, Zhang Xiaohua, Wang Ouchen
Abstract excerpt
The role of telomerase reverse transcriptase (TERT) gene promoter mutations in the aggressiveness of papillary thyroid cancer (PTC) remains to be further investigated. Here we examined the relationship of TERT promoter mutations and BRAF V600E with the clinicopathological features of PTC in 653 patients. Sanger sequencing of genomic DNA from primary PTC tumors was performed for mutation detection and...
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