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Article

An isochromosome confers drug resistance in vivo by amplification of two genes, ERG11 and TAC1.

Molecular microbiology - 1 May 2008

Selmecki Anna, Gerami-Nejad Maryam, Paulson Carsten, Forche Anja, Berman Judith

Abstract excerpt

Acquired azole resistance is a serious clinical problem that is often associated with the appearance of aneuploidy and, in particular, with the formation of an isochromosome [i(5L)] in the fungal opportunist Candida albicans. Here we exploited a series of isolates from an individual patient during the rapid acquisition of fluconazole resistance (Flu(R)). Comparative genome hybridization arrays revealed that the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18363649
DOI: 10.1111/j.1365-2958.2008.06176.x

Genes

TAC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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