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Article

An architectural framework that may lie at the core of the postsynaptic density.

Science (New York, N.Y.) - 27 Jan 2006

Baron Marisa K, Boeckers Tobias M, Vaida Bianca, Faham Salem, Gingery Mari, Sawaya Michael R, Salyer Danielle, Gundelfinger Eckart D, Bowie James U

Abstract excerpt

The postsynaptic density (PSD) is a complex assembly of proteins associated with the postsynaptic membrane that organizes neurotransmitter receptors, signaling pathways, and regulatory elements within a cytoskeletal matrix. Here we show that the sterile alpha motif domain of rat Shank3/ProSAP2, a master scaffolding protein located deep within the PSD, can form large sheets composed of helical fibers stacked side...

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Identifiers

PMID: 16439662
DOI: 10.1126/science.1118995

Genes

PSD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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