Article
Screening for inter-individual splicing differences in human GSTM4 and the discovery of a single nucleotide substitution related to the tandem skipping of two exons.
Gene - 1 Sept 2006
Denson Jackie, Xi Zongying, Wu Yongchun, Yang Wenjian, Neale Geoffrey, Zhang Jiong
Abstract excerpt
The glutathione S-transferase Mu class (GSTM) genes encode phase II metabolism enzymes that are involved in the detoxification of various carcinogens and drugs. Some genetic polymorphisms in GSTM genes are related to disease phenotypes and drug-metabolism differences in the population. Polymorphisms that alter gene-splicing patterns are functionally very important because they often lead to the insertion or...
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