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Article

Functionally relevant genetic variants of glutathione S-transferase GSTM5 in cynomolgus and rhesus macaques.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Aug 2019

Uno Yasuhiro, Murayama Norie, Tamura Kazuaki, Yamazaki Hiroshi

Abstract excerpt

Glutathione S-transferase (GST) is a family of enzymes important for conjugation with glutathione of endogenous and exogenous compounds. Human GSTM1 null allele is associated with toxicity and cancers. Cynomolgus and rhesus macaques have molecular and enzymatic similarities of GSTs to humans; however, genetic variants have not been investigated. In macaques, instead of pseudogenized GSTM1, GSTM5 is a predominant...

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PMID: 30216105
DOI: 10.1080/00498254.2018.1524187

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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