Article
Pancreatic cancer in Europe: Ki-ras gene mutation pattern shows geographical differences.
International journal of cancer - 15 Apr 1994
Scarpa A, Capelli P, Villaneuva A, Zamboni G, Lluìs F, Accolla R, Mariuzzi G, Capellà G
Abstract excerpt
Seventy-seven pancreatic adenocarcinomas (60 Spanish and 17 Italian) were tested for Ki-ras gene mutations by analysis of polymerase chain reaction amplified sequences. Mutations involving codon 12 (GGT; gly) were detected in 16 Italian and 46 Spanish cases (80.5% in total). All Italian mutations involved the second base and were G to A transitions (GAT; asp) in 8 cases and G to T transversions (GTT; val) in the...
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