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Article

Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors possessing augmented P2' side chains.

Bioorganic & medicinal chemistry letters - 15 Feb 2006

Smith Amos B, Charnley Adam K, Harada Hironori, Beiger Jason J, Cantin Louis-David, Kenesky Craig S, Hirschmann Ralph, Munshi Sanjeev, Olsen David B, Stahlhut Mark W, Schleif William A, Kuo Lawrence C

Abstract excerpt

A series of monopyrrolinone-based HIV-1 protease inhibitors possessing rationally designed P2' side chains have been synthesized and evaluated for activity against wild-type HIV-1 protease. The most potent inhibitor displays subnanomolar potency in vitro for the wild-type HIV-1 protease. Additionally, the monopyrrolinone inhibitors retain potency in cellular assays against clinically significant mutant forms of...

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Identifiers

PMID: 16298527
DOI: 10.1016/j.bmcl.2005.11.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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