Article
Gene expression profiling of acute myeloid leukemia with translocation t(8;16)(p11;p13) and MYST3-CREBBP rearrangement reveals a distinctive signature with a specific pattern of HOX gene expression.
Cancer research - 15 Jul 2006
Camós Mireia, Esteve Jordi, Jares Pedro, Colomer Dolors, Rozman María, Villamor Neus, Costa Dolors, Carrió Ana, Nomdedéu Josep, Montserrat Emili, Campo Elías
Abstract excerpt
Acute myeloid leukemia (AML) with translocation t(8;16)(p11;p13) is an infrequent leukemia subtype with characteristic clinicobiological features. This translocation leads to fusion of MYST3 (MOZ) and CREBBP (CBP) genes, probably resulting in a disturbed transcriptional program of a myelomonocytic precursor. Nonetheless, its gene expression profile is unknown. We have analyzed the gene expression profile of 23...
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