Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

HOX expression patterns identify a common signature for favorable AML.

Leukemia - 1 Nov 2008

Andreeff M, Ruvolo V, Gadgil S, Zeng C, Coombes K, Chen W, Kornblau S, Barón A E, Drabkin H A

Abstract excerpt

Deregulated HOX expression, by chromosomal translocations and myeloid-lymphoid leukemia (MLL) rearrangements, is causal in some types of leukemia. Using real-time reverse transcription-PCR, we examined the expression of 43 clustered HOX, polycomb, MLL and FLT3 genes in 119 newly diagnosed adult acute myeloid leukemias (AMLs) selected from all major cytogenetic groups. Downregulated HOX expression was a consistent...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gene Expression Regulation, Leukemic
Share to Histone-Lysine N-Methyltransferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Myeloid Ecotropic Viral Integration Site 1 Protein

Share to Myeloid-Lymphoid Leukemia Protein

Share to Nucleophosmin

Share to Polycomb-Group Proteins

Share to Polycomb Repressive Complex 1

Share to RNA, Neoplasm

Source

Open in PubMed Open full text

Identifiers

PMID: 18668134
DOI: 10.1038/leu.2008.198
PMCID: PMC2676170

Genes

FLT3
HOXA9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HOX expression patterns identify a common signature for favorable AML.PMID 18668134Read ↗

The Role of Hox Proteins in Leukemogenesis: Insights Into Key Regulatory Events in HematopoiesisSemantic proximity Read ↗

Hox expression in AML identifies a distinct subset of patients with intermediate cytogeneticsSemantic proximity Read ↗

Elevated HOX gene expression in acute myeloid leukemia is associated with NPM1 mutations and poor survivalSemantic proximity Read ↗

Gene expression profiling of Polycomb, Hox and Meis genes in patients with acute myeloid leukaemiaSemantic proximity Read ↗

<i>Hox</i> gene Dysregulation in Acute Myeloid LeukemiaSemantic proximity Read ↗

Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemiaSemantic proximity Read ↗

The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature.Semantic proximity Read ↗

The Role of the HOXA Gene Family in Acute Myeloid LeukemiaSemantic proximity Read ↗

Higher expression levels of the HOXA9 gene, closely associated with MLL-PTD and EZH2 mutations, predict inferior outcome in acute myeloid leukemiaSemantic proximity Read ↗

Overexpression of HOXA10 is associated with unfavorable prognosis of acute myeloid leukemiaSemantic proximity Read ↗

Identification of HOXA9 methylation as an epigenetic biomarker predicting prognosis and guiding treatment choice in acute myeloid leukemiaSemantic proximity Read ↗

Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemiasSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.