Article
Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia.
Blood - 15 Aug 2007
Bullinger Lars, Rücker Frank G, Kurz Stephan, Du Juan, Scholl Claudia, Sander Sandrine, Corbacioglu Andrea, Lottaz Claudio, Krauter Jürgen, Fröhling Stefan, Ganser Arnold, Schlenk Richard F, Döhner Konstanze, Pollack Jonathan R, Döhner Hartmut
Abstract excerpt
Core binding factor (CBF) leukemias, characterized by either inv(16)/t(16;16) or t(8;21), constitute acute myeloid leukemia (AML) subgroups with favorable prognosis. However, there exists substantial biologic and clinical heterogeneity within these cytogenetic groups that is not fully reflected by the current classification system. To improve the molecular characterization we profiled gene expression in a large...
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