Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study.

doi:10.1111/bjh.17336

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Article

Characteristics and outcome of patients with acute myeloid leukaemia and t(8;16)(p11;p13): results from an International Collaborative Study.

British journal of haematology - 1 Mar 2021

Kayser Sabine, Hills Robert K, Langova Ralitsa, Kramer Michael, Guijarro Francesca, Sustkova Zuzana, Estey Elihu H, Shaw Carole M, Ráčil Zdeněk, Mayer Jiri, Zak Pavel, Baer Maria R, Brunner Andrew M, Szotkowski Tomas, Cetkovsky Petr, Grimwade David, Walter Roland B, Burnett Alan K, Ho Anthony D, Ehninger Gerhard, Müller-Tidow Carsten, Platzbecker Uwe, Thiede Christian, Röllig Christoph, Schulz Angela, Warsow Gregor, Brors Benedikt, Esteve Jordi, Russell Nigel H, Schlenk Richard F, Levis Mark J

Abstract excerpt

In acute myeloid leukaemia (AML) t(8;16)(p11;p13)/MYST3-CREBBP is a very rare abnormality. Previous small series suggested poor outcome. We report on 59 patients with t(8;16) within an international, collaborative study. Median age was 52 (range: 16-75) years. AML was de novo in 58%, therapy-related (t-AML) in 37% and secondary after myelodysplastic syndrome (s-AML) in 5%. Cytogenetics revealed a complex...

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PMID: 33529373
DOI: 10.1111/bjh.17336

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