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An IRF-3-, IRF-5-, and IRF-7-Independent Pathway of Dengue Viral Resistance Utilizes IRF-1 to Stimulate Type I and II Interferon Responses

1 Nov 2017

Abstract excerpt

Interferon-regulatory factors (IRFs) are a family of transcription factors (TFs) that translate viral recognition into antiviral responses, including type I interferon (IFN) production. Dengue virus (DENV) and other clinically important flaviviruses are suppressed by type I IFN. While mice lacking the type I IFN receptor ( Ifnar1 −/− ) succumb to DENV infection, we found that mice deficient in three transcription...

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PMID: 29117564
DOI: 10.1016/j.celrep.2017.10.054

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