Selective activation of Th1- and Th2-like cells in vivo--response to human collagen IV.

Abstract excerpt

Mice immunized with human collagen IV develop either antibody responses or T-cell proliferative responses as a function of the MHC genotype of the immunized mice. CD4+ T cells, similar to Th1 and Th2 cells, participate in these two types of responses, with CD4+ T-cell proliferative responses associating with IL-2 and IFN gamma release, and antibody production associating with CD4+ T-cell IL-4 and IL-5 release....

Topics

• Animals
• CD4-Positive T-Lymphocytes
• Clone Cells
• Collagen
• Genotype
• Humans
• Immunodominant Epitopes
• Lymphocyte Activation
• Major Histocompatibility Complex
• T-Lymphocytes, Helper-Inducer