I-Aq and I-Ap bind and present similar antigenic peptides despite differing in their ability to mediate susceptibility to autoimmune arthritis.

doi:10.3109/08916930109001961

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Article

I-Aq and I-Ap bind and present similar antigenic peptides despite differing in their ability to mediate susceptibility to autoimmune arthritis.

Autoimmunity - 1 Jan 2001

Brand D D, Whittington K B, Rosloniec E F

Abstract excerpt

Susceptibility to collagen induced arthritis (CIA) in the murine model is linked to expression of the MHC class II alleles, I-Aq and I-Ar. We have examined the molecular basis for this MHC-linked susceptibility by studying the antigen presentation function of two class II molecules, I-Aq and I-Ap, that are closely related yet differ in mediating susceptibility to CIA. These class II molecules differ by only 4...

Topics

Amino Acid Substitution
Animals
Arthritis, Experimental
Autoimmune Diseases
Collagen Type II
Female
Genes, MHC Class II
Genetic Predisposition to Disease
Histocompatibility Antigens
Male
Mice
Mice, Inbred DBA
T-Lymphocytes

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PMID: 11905843
DOI: 10.3109/08916930109001961

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