Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Autoreactivity in collagen-induced arthritis of rats: a potential role for T cell responses to self MHC peptides.

Journal of autoimmunity - 1 Jun 2002

Catchpole Brian, Ward Frank J, Hamblin Anne S, Staines Norman A

Abstract excerpt

Collagen-induced arthritis (CIA) is a chronic inflammatory arthropathy of rats which follows immunization with bovine type II collagen (bCII). T cell lines generated from arthritic rats have been shown to be self-reactive and proliferate in an autologous MLR, which is MHC-dependent. However, the peptides which drive this autoreactive response remain to be elucidated. T cell lines, generated initially to bCII,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Arthritis, Experimental
Share to Autoimmunity
Share to Cattle

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Collagen Type II

Share to Major Histocompatibility Complex

Share to Molecular Mimicry

Share to T-Lymphocytes

Source

Identifiers

PMID: 12144808
DOI: 10.1006/jaut.2002.0585

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Autoreactivity in collagen-induced arthritis of rats: a potential role for T cell responses to self MHC peptides.PMID 12144808Read ↗

Autologous mixed lymphocyte responses in experimentally-induced arthritis of the Lewis rat.Semantic proximity Read ↗

Breaking T cell tolerance against self type II collagen in HLA-DR4-transgenic mice and development of autoimmune arthritis.Semantic proximity Read ↗

T cell immunity to type II collagen in the biobreeding rat: the identification and characterization of RT1u-restricted T cell epitopes on alpha 1(II).Semantic proximity Read ↗

Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis.Semantic proximity Read ↗

Intrinsic tolerance in autologous collagen-induced arthritis is generated by CD152-dependent CD4+ suppressor cells.Semantic proximity Read ↗

T cell reactivity to self and allogeneic MHC-peptides.Semantic proximity Read ↗

HLA-DQ8 transgenic mice are highly susceptible to collagen-induced arthritis: a novel model for human polyarthritis.Semantic proximity Read ↗

Collagen-Induced Arthritis as a Model of Rheumatoid ArthritisSemantic proximity Read ↗

Collagen-induced arthritis in the BB rat. Prevention of disease by treatment with CTLA-4-Ig.Semantic proximity Read ↗

Identification of T cell autoepitopes that cross-react with the C-terminal segment of the M protein of group A streptococciSemantic proximity Read ↗

Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis.Semantic proximity Read ↗

Identification of an immunodominant type‐II collagen peptide recognized by T cells in H‐2<sup>q</sup> mice: self tolerance at the level of determinant selectionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.