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Article

SLCO1B1 polymorphism and oral antidiabetic drugs.

Basic & clinical pharmacology & toxicology - 1 Oct 2010

Kalliokoski Annikka, Neuvonen Pertti J, Niemi Mikko

Abstract excerpt

Organic anion-transporting polypeptide 1B1 (OATP1B1; gene: SLCO1B1) is an influx transporter expressed on the sinusoidal membrane of human hepatocytes, where it mediates the uptake of its substrates from blood into liver. In vitro, the SLCO1B1 c.521T>C (p.Val174Ala) single-nucleotide polymorphism (SNP) has been associated with reduced and the c.388A>G (p.Asn130Asp) SNP with both enhanced and reduced transport...

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PMID: 20406215
DOI: 10.1111/j.1742-7843.2010.00581.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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