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Article

Amino acid substitutions in the pore of rat glutamate receptors at sites influencing block by polyamines.

The Journal of physiology - 15 Oct 1999

Panchenko V A, Glasser C R, Partin K M, Mayer M L

Abstract excerpt

1. The effect on polyamine block of mutations at the Q/R site and the conserved negative charge +4 site in AMPA and kainate receptors was studied using the rat glutamate receptor GluR6 expressed in Xenopus oocytes and human embryonic kidney (HEK) cells. 2. Introduction of negative charge at the Q/R site increased the equilibrium dissociation constant at 0 mV (Kd(0)) for spermine from 1.3 to 4.0 microM (Q590E);...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10523404
DOI: 10.1111/j.1469-7793.1999.t01-1-00337.x
PMCID: PMC2269595

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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