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Article

Hypotensive effect associated with a phospholipase C-delta 1 gene mutation in the spontaneously hypertensive rat.

Biochemical and biophysical research communications - 30 Sept 1992

Katsuya T, Higaki J, Miki T, Kohara K, Yagisawa H, Tanase H, Mikami H, Serikawa T, Nojima H, Ogihara T

Abstract excerpt

To identify the genes responsible for blood pressure in the spontaneously hypertensive rat strain, we performed a cosegregation analysis between the genotype and blood pressure in a set of male F2 rats obtained by crossmating SHR with Wistar-Kyoto rats, a parental normotensive strain. Our investigation revealed that the phospholipase C-delta 1 polymorphism, which resulted in missense mutation, cosegregates with...

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PMID: 1358065
DOI: 10.1016/0006-291x(92)90452-q

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Hypotensive effect associated with a phospholipase C-delta 1 gene mutation in the spontaneously hypertensive rat.PMID 1358065Read ↗

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