Article
Hypotensive effect associated with a phospholipase C-delta 1 gene mutation in the spontaneously hypertensive rat.
Biochemical and biophysical research communications - 30 Sept 1992
Katsuya T, Higaki J, Miki T, Kohara K, Yagisawa H, Tanase H, Mikami H, Serikawa T, Nojima H, Ogihara T
Abstract excerpt
To identify the genes responsible for blood pressure in the spontaneously hypertensive rat strain, we performed a cosegregation analysis between the genotype and blood pressure in a set of male F2 rats obtained by crossmating SHR with Wistar-Kyoto rats, a parental normotensive strain. Our investi...
Topics
- Animals
- Base Sequence
- Blood Pressure
- Chromosome Mapping
- Hypertension
- Male
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Rats
- Rats, Inbred SHR
- Rats, Inbred WKY