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Article

Exploiting reaction intermediates of the ATPase reaction to elucidate the mechanism of transport by P-glycoprotein (ABCB1).

The Journal of biological chemistry - 8 Sept 2006

Sauna Zuben E, Nandigama Krishnamachary, Ambudkar Suresh V

Abstract excerpt

The transport cycle of ABC transporters in general and P-glycoprotein in particular has been extensively studied, but the molecular mechanism remains controversial. We identify stable reaction intermediates in the progression of the P-glycoprotein-mediated ATPase reaction equivalent to the enzyme...

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Share to Adenosine Triphosphatases
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Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

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Identifiers

PMID: 16844693
DOI: 10.1074/jbc.M601917200

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-16844693-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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