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Article

A short cross-linker activates human P-glycoprotein missing a catalytic carboxylate.

Biochemical pharmacology - 1 Dec 2017

Loo Tip W, Clarke David M

Abstract excerpt

P-glycoprotein (P-gp) is an ATP-dependent drug pump that protects us from toxic agents and confers multidrug resistance. It has a tweezer-like structure with each arm consisting of a transmembrane domain (TMD) and a nucleotide-binding domain (NBD). Drug substrates bind to sites within the TMDs to activate ATPase activity by promoting a tweezer-like closing of the gap between the NBDs. The catalytic carboxylates...

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Identifiers

PMID: 28837794
DOI: 10.1016/j.bcp.2017.08.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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