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Article

High affinity ATP/ADP analogues as new tools for studying CFTR gating.

The Journal of physiology - 1 Dec 2005

Zhou Zhen, Wang Xiaohui, Li Min, Sohma Yoshiro, Zou Xiaoqin, Hwang Tzyh-Chang

Abstract excerpt

Previous studies using non-hydrolysable ATP analogues and hydrolysis-deficient cystic fibrosis transmembrane conductance regulator (CFTR) mutants have indicated that ATP hydrolysis precedes channel closing. Our recent data suggest that ATP binding is also important in modulating the closing rate. This latter hypothesis predicts that ATP analogues with higher binding affinities should stabilize the open state more...

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Share to Adenosine Diphosphate
Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Cystic Fibrosis Transmembrane Conductance Regulator

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Source

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Identifiers

PMID: 16223764
DOI: 10.1113/jphysiol.2005.095083
PMCID: PMC1464241

Genes

CFTR
PNP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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