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Article

Transition-state formation in ATPase-negative mutants of human MDR1 protein.

Biochemical and biophysical research communications - 5 Oct 2000

Szakács G, Ozvegy C, Bakos E, Sarkadi B, Váradi A

Abstract excerpt

In this work we have studied the partial catalytic reactions in MDR1 variants carrying mutations in the conserved Walker A region (K433M and K1076M) of either the N-terminal or C-terminal ABC domain. Both mutations have been demonstrated to cause a loss of drug transport, drug-stimulated ATPase, and vanadate-dependent nucleotide trapping activity. Here we show that these mutants still allow transition state...

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Identifiers

PMID: 11027628
DOI: 10.1006/bbrc.2000.3576

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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