Article
Genomic variations and transcriptional regulation of the human mu-opioid receptor gene.
European journal of pain (London, England) - 1 May 2007
Bayerer Bettina, Stamer Ulrike, Hoeft Andreas, Stüber Frank
Abstract excerpt
The mu-opioid receptor (MOR1) is a target of endogenous and exogenous opioids and plays a pivotal role for anesthesia and analgesia. Variations in the 5' flanking sequence of the mu-opioid receptor gene may influence transcriptional regulation and ultimately alter protein expression of MOR1. In the present study we investigated the influence of eight single nucleotide polymorphisms (SNP) within the mu-opioid...
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