Article
Regulation of mu-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site.
The Journal of biological chemistry - 23 Nov 2001
Kraus J, Borner C, Giannini E, Hickfang K, Braun H, Mayer P, Hoehe M R, Ambrosch A, Konig W, Hollt V
Abstract excerpt
Morphine and the endogenous opioid peptide beta-endorphin exert neuromodulatory as well as immunomodulatory effects, which are transduced by mu-opioid receptors. In this report we show that stimulation with interleukin-4 induces mu-opioid receptor transcripts in human primary blood cells (T cells and polymorphonuclear leukocytes), immune cell lines (Raji, U-937, and HMEC-1), and dendritic cells. In nonstimulated...
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