Article
Inactivation of DNA adenine methyltransferase alters virulence factors in Actinobacillus actinomycetemcomitans.
Oral microbiology and immunology - 1 Aug 2006
Wu H, Lippmann J E, Oza J P, Zeng M, Fives-Taylor P, Reich N O
Abstract excerpt
DNA adenine methyltransferase (DAM) plays critical roles in diverse biological pathways in gram-negative bacteria, and specifically in regulating the expression of virulence genes in several organisms. Actinobacillus actinomycetemcomitans plays an important role in the pathogenesis of juvenile and adult periodontal disease, yet little is known about its mechanisms of gene regulation. DAM is shown here to directly...
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