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Article

Alteration of DNA adenine methylase (Dam) activity in Pasteurella multocida causes increased spontaneous mutation frequency and attenuation in mice.

Microbiology (Reading, England) - 1 Aug 2003

Chen Liang, Paulsen Daniel B, Scruggs Daniel W, Banes Michelle M, Reeks Brenda Y, Lawrence Mark L

Abstract excerpt

Pasteurella multocida is one of the primary bacterial pathogens associated with bovine respiratory disease (BRD) complex. Relatively few virulence factors of P. multocida have been characterized, and there is a need for improved vaccines for prevention of BRD. In other Gram-negative species, DNA adenine methylase (Dam) regulates the expression of virulence genes, and appropriate expression of Dam is required for...

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Share to Mice, Inbred BALB C

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Identifiers

PMID: 12904568
DOI: 10.1099/mic.0.26251-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Alteration of DNA adenine methylase (Dam) activity in Pasteurella multocida causes increased spontaneous mutation frequency and attenuation in mice.PMID 12904568Read ↗

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